Selected Publications

Brissett NC, Pitcher RS, Juarez R, Picher AJ, Green AJ, Dafforn TR, Fox GC, Blanco L* and Doherty AJ, 2007. Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science 318:456-459. (IF 26.3)


Aguilera A, Gomez-Gonzalez B, 2008. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 9(3):204-217. (IF 24.1)

Baños B, Lázaro J M,Villar L, Salas M, de Vega M, 2008. Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. J. Mol. Biol. 384: 1019-1028. (IF 4.146)

Baños B, Lázaro J M,Villar L, Salas M, de Vega M, 2008. Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucl. Acids Res. 36:5736-5749. (IF 6.8)

Borlado LR, Mendez J. 2008. CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. Carcinogenesis 29:237-243. (IF 4.9)

Colomina N, Ferrezuelo F, Wang H, Aldea M, Gari E. 2008. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. J Biol Chem 283: 28670-28679. (IF 5.5)

Davis, L., Rozalén, A.E., Moreno, S. , Smith, G.R. and Martín-Castellanos, C. 2008. Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination. Current Biol. 18:849-854. (IF 10.7)

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Méndez, J., Moreno, S. , and Malumbres, M. 2008. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nature Cell Biol 10:802-811. (IF 17.7)

Huertas P, Cortes-Ledesma F, Sartori AA, Aguilera A, Jackson SP, 2008. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455:689-692 (IF 31.4)

Ibarra, A., Schwob, E., and Méndez, J. 2008. Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci USA 105: 8956-8961. [*]

Losada A. 2008. The regulation of sister chromatid cohesion. Biochim. Biophys. Acta 1786:41-48

Pérez-Hidalgo, L., Rozalén, A.E., Martín-Castellanos, C and Moreno, S. 2008. Slk1 is a meiosis-specific Sid2-related kinase that coordinates meiotic nuclear division with growth of the forespore membrane. J. Cell Science 121:1383-1392. (IF 6.2)

Rivera, T., and Losada, A. 2009. Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts. Chromosoma 118:223-33. (IF 5.1)

Salas M, Blanco L, Lazaro JM, de Veja M. 2008. The bacteriophage phi29 DNA polymerase. IUBMB Life 60:82-85. (IF 2.3)

Serrano-Heras, G. Bravo, A. and Salas M. 2008. Phage phi29 protein p56 prevents viral DNA replication impairment caused by uracil excision activity of uracil-DNA glycosylase. Proc. Natl. Acad. Sci. 105:19044-19049. [*]

Vázquez, M. V., Rojas, V. and Tercero, J. A. 2008. Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA. DNA Repair 7:1693-1704. (IF 5.0)


Andrade P, Martín MJ, Juárez R, López de Saro F, Blanco L. 2009. Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. Proc. Natl. Acad. Sci. 106:16203-16208.

Cambray S, Pedraza N, Rafel M, Garí E, Aldea M, Gallego C. 2009. Protein kinase KIS localizes to RNA granules and enhances local translation. Mol. Cell. Biol. 29:726-735 (IF 5.9)

Gomez-Gonzalez B, Aguilera A. 2009. R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX. Nucl. Acids Res. 37(13): 4315-4321 (IF 6.8)

Gomez-Gonzalez B, Felipe-Abrio I, Aguilera A. 2009. The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol. Cell. Biol 29(19):5203-5213 (IF 5.9)

Gozalbo-López B, Andrade P, Terrados G, de Andrés B, Serrano N, Cortegano I, Palacios B, Bernad A, Blanco L, Marcos MA, Gaspar ML. 2009. A role for DNA polymerase mu in the emerging DJH rearrangements of the postgastrulation mouse embryo. Mol. Cell Biol. 29:1266-1275. (IF 5.9)

Ibarra B, Chemla YR, Plyasunov S, Smith SB, Lazaro JM, Salas M, Bustamante C. 2009. Proofreading dynamics of a processive DNA polymerase. EMBO J. 28:2794-2802 (IF 8.2)

Mas G, de Nadal E, Dechant R, de la Concepción ML, Logie C, Jimeno-González S, Chávez S, Ammerer G, Posas F. 2009. Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes. EMBO J. 28:326-36. (IF 8.2)

Muños-Espin D, Daniel R, Hawai Y, Carballido-Lopz R, Castilla-Llorente V, Errington J, Meijer W, Salas M. 2009. The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria. Proc. Natl. Acad. Sci. 106(32):13347-13352

Pardo B, Gomez-Gonzalez B, Aguilera A. 2009. DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship. Cell Mol. Life Sci. 66:1039-1056 (5.5)

Ruiz J F, Gomez-Gonzalez B, Aguilera A. 2009. Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication. Mol. Cell. Biol 29(20):5441-5454 (5.9)

Segurado M, Tercero JA. 2009. The S-phase checkpoint: targeting the replication fork. Biol Cell. 101(11):617-27

Serrano A, Rodríguez-Corsino M, Losada A. 2009. Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells. PLoS One 4: e5118

Tercero JA. 2009. Density transfer as a method to analyze the progression of DNA replication forks. Methods Mol Biol. 521:203-13

Terrados G, Capp J-P, Canitrot Y, García-Díaz M, Bebenek K, Kirchhoff T, Villanueva A, Boudsoq F, Bergoglio V, Cazaux C, Kunkel TA, Hoffmann JS, Blanco L. 2009. Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. PLoS ONE 4(10): e7290. doi:10.1371/journal.pone.0007290

Yaakov G, Duch A, Garcia-Rubio M, Clotet J, Jiménez J, Aguilera A, Posas F. 2009. The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress. Mol. Biol. Cell. 20:3572-3582 (IF 5.5)


Baños, B. Villar, L. Salas, M. and de Vega, M. Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites. 2010. Proc. Natl. Acad. Sci. USA. 107, 19219-19224.

Bermúdez-López M, Ceschia A, de Piccoli G, Colomina N, Pasero P, Aragón L, and Torres-Rosell J. The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. 2010. Nucleic Acids Res. 38:6502-12.

Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L and Doherty AJ. Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase. 2010. Mol. Cell41:221-231.

Capp JP, Boudsocq F, Bergoglio V, Trouche D, Cazaux C, Blanco L, Hoffmann JS, and Canitrot Y. The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. 2010. Carcinogenesis 31, 1742-1747.

Cotobal C, Segurado M and Antequera F. Structural diversity and dynamics of genomic replication origins in Schizosaccharomyces pombe. 2010. EMBO J. 29:934-42.

de Vega M, Lázaro JM, Mencía M, Blanco L, and Salas M. Improvement of f29 DNA polymerase amplification performance by fusion of DNA binding motifs. 2010. Proc. Natl. Acad. Sci. USA. 107, 16506-16511.

Ferreiro I, Joaquin M, Islam A, Gomez-Lopez G, Barragan M, Lombardía L, Domínguez O, Pisano DG, Lopez-Bigas N, Nebreda AR and Posas F. Whole genome analysis of p38 SAPK-mediated gene expression upon stress. 2010 BMC Genomics. 11:144.

Ferreiro I, Barragan M, Gubern A, Ballestar E, Joaquin M and Posas F. The p38 SAPK is recruited to chromatin via its interaction with transcription factors. 2010. J. Biol Chem. 285(41): 31819-28.

Ferrezuelo F, Colomina N, Futcher B and Aldea M. The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle. 2010. Genome Biol. 11:R67

Guillou, E. Ibarra, A. Coulon, V.J. Casado-Vela, J Casal, I. Schwob, E. Losada A. and Méndez, J. Cohesin organizes chromatin loops at DNA replication factories. 2010. Genes Dev. 24(24):2812-22.

Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S, Yamano, H, Cañamero, M, Malumbres, M. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. 2010 Cancer Cell 18, 641-654

Moriel-Carretero, M. and Aguilera, A. A postincision-deficient TFIIH causes replication fork breakage and uncovers alternative Rad51- or Pol32-mediated restart mechanisms. 2010. Mol. Cell 37 (5):690-701.

Muñóz-Espín, D. Holguera, I. Ballesteros-Plaza, D. Carballido-López R. and Salas M. Viral terminal protein directs early organization of phage DNA replication at the bacterial nucleoid 2010. Proc. Natl. Acad. Sci. USA. 107, 16548-16553.

Nieto, C., Almendinger, J., Gysi, S., Kaech, A., Hengartner, M., Schnabel, R., Moreno, S. and Cabello, J. ccz-1 mediates the digestion of apoptotic corpses in C. elegans. 2010. J. Cell Sci. 123, 2001-2007.

Quintales L, Sánchez M and Antequera F. Analysis of DNA strand-specific differential expression with high density tiling microarrays. 2010. BMC Bioinformatics 11: 136

Regot S, Macia J, Conde N, Peeters T, Kentaro F, Kjellen J, Hohmann, S. de Nadal, E, Posas F and Solé R. Distributed biological computation with multicellular engineered networks. 2011. Nature, DOI:10.1038/nature09679. 469(7329):207-11

Sardina JL, López-Ruano G, ... Sánchez-Yagüe J and Hernández-Hernández A. p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation. 2010. Cell Death Differ. 17:1842-54

Valbuena, N. and Moreno, S. TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast. 2010. PloS ONE 5, e11514.

Warringer J, Hult M, Regot S, Posas F and Sunnerhagen P. The HOG pathway dictates the short-term translational response after hyperosmotic shock. 2010. Mol Biol Cell. 21(17): 3080-92.


Adrover MÀ, Zi Z, Duch A, Schaber J, González-Novo A, Jimenez J, Nadal-Ribelles M, Clotet J, Klipp E, Posas, F. Time-dependant quantitive multicomponent control of the GB-S network by the stress-activated protein kinase Hog1 upon osmostress. 2011. Sci. Signal. 4(192):ra63

Asensio, J.L. Pérez-Lago, L. Lázaro, J.M. González, C. Serrano-Heras, G. Salas, M. Novel dimeric structure of phage ø29-encoded protein p56: Insights into uracil-DNA glycosylase inhibiton. 2011. Nucl.Acids Res. 39(22):9779-9788.

Bermejo, R. Capra, T. Jossen, R. Colosio, A. Frattini, C. Carotenuto, W. Cocito, A. Doksani, Y. Klein, H. Gomez-Gonzalez, B. Aguilera, A. Katou, Y. Shirahige, K. Foiani, M. The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. 2011. Cell. 146:233-246

Bernad R, Sánchez P, Rivera T, Rodríguez-Corsino M, Boyarchuk E, Vassias I, Ray-Gallet D, Arnaoutov A, Dasso M, Almouzni G, Losada A. Xenopus HJURP and condensin II are required for CENP-A assembly. 2011. J Cell Biol. 192: 569-82.

Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L, Doherty AJ. Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. 2011. Mol Cell. 41(2):221-31.

Bonfils, S.G.O., Rozalén, A.E., Smith, G.R., Moreno, S. and Martín-Castellanos, C. Functional Interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex. 2011. Journal of Cell Science 124, 1328-1338.

De Castro, E., Soriano, I., Marín, L., Serrano, R., Quintales, L. Antequera, F. Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast. 2011. EMBO J. 31, 124–137

de la Loza, M.C.D. Gallardo, M. Garcia-Rubio, ML. Izquierdo, A. Herrero, E. Aguilera, A. Wellinger, R. Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability. 2011. Nucleic Acids Res. 8:620-626.

de Vega, M. Salas, M. Protein-primed replication of bacteriophage ø29 DNA. DNA Replication/Book. Ed. By Jelena Kusic. 2011. INTECH. ISBN 978-953-307-775-8.

Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. 2011. J Cell Biol. 194 (4):567-79.

Dominguez-Sanchez MS, Saez, C. Japon, MA. Aguilera, A. Luna, R. Differential expression of THOC1 and ALLY mRNP biogenesis/export factors in human cancers. 2011. BMC Cancer 11:77.

Domínguez-Sanchez MS, Barroso S, Gomez-Gonzalez B, Luna R, Aguilera A. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. 2011. PLoS Genetics. 7(12):e1002386.

Fernández RMH, Ruiz-Miró M, Dolcet X, Aldea M, Garí E. Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility. 2011. Oncogene 30: 1936-1946.

Garcia-Rubio ML, Aguilera A. Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes. 2011. Nucleic Acids Res. 40(3):1050-64

Gomez-Gonzalez, B. Garcia-Rubio, M. Bermejo, R. Gaillard, H. Shirahige, K. Marin, A. Foiani, M. Aguilera, A. Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. 2011. EMBO J. 30(15):3106-3119.

Herrero, A.B. and Moreno, S. Lsm1 promotes genomic stability by controlling histone mRNA decay. 2011. EMBO J. 30:2008-2018

Hohl, M. Kwon, Y. Muñoz Galvan, S. Xue, X. Tous, C. Aguilera, A.P. Sung, P. Petrini, J.H.J. The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. 2011. Nat. Struct. Mol. Biol. 18(10):1124-1131

Holt, J.A., Tran, S.M.T., Stewart, J.L., Minahan, K., García-Higuera, I., Moreno, S. and Jones, K.T. The APC/C activator FZR1 co-ordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. 2011. Development 138, 905-913

Mischo. H:E., Gómez-González, B., Grzechnik, P., Rondón, A.G., Wei, W, Steinmetz, L., Aguilera, A.* and Proudfoot, N.J.*. Yeast Sen1 helicase protects the genome from transcription-associated instability. 2011. Mol. Cell 41 (1): 1-12 (*corresponding authors)

Moriel-Carretero M, Tous C, Aguilera A. Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1. 2011. Proc. Natl. Acad. Sci. USA. 108:15300-5

Neukomm, L.J., Andreas P., Frei, A.P., Cabello, J., Ma, X., Haney, L.B., Ravichandran, K.S., Moreno, S. and Hengartner, M.O. RhoGAP SRGP-1 promotes survival and antagonizes clearance of apoptotic cells in C. elegans. 2011. Nature Cell Biology 13, 79-86.

Pérez-Lago, L. Serrano-Heras, G. Baños, B. Lázaro, J.M. Alcorlo, M. Villar, L. and Salas, M. Characterization of /Bacillus subtilis/ Uracil-DNA glycosylase and its inhibition by phage ø29 protein p56. Mol. 2011. Microbiol. 80:1657-1666

Regot S, Macia J, Conde N, Furukawa K, Kjellén J, Peeters T, Hohmann S, de Nadal E, Posas F, Solé R. Distributed biological computation with multicellular engineered networks. 2011. Nature. 469(7329):207-11.

Ruiz, J.F. Gomez-Gonzalez, B. Aguilera A. AID induced double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. 2011. PLos Genetics 7(2): e1002009

Ruiz-Miró M, Colomina N, Fernández RMH, Garí E, Gallego C, Aldea M. Translokin interacts with cyclin D1 and prevents its nuclear accumulation in quiescent cells. 2011. Traffic 12: 549-562

Sanchez, P. Losada, A. New clues to understand how CENP-A maintains centromere identity. 2011. Cell Division 6:11

Sanchez-Berrondo J, Mesa P, Ibarra A, Martínez-Jiménez MI, Blanco L, Méndez J, Boskovic J, Montoya G. 2011. Molecular architecture of a multifunctional MCM complex. Nucleic Acids Res. 40(3):1366-80. doi: 10.1093/nar/gkr831.

Sardina, J.L., López-Ruano, G., Sánchez-Sánchez, B., Llanillo, M., Hernández-Hernández, A. Reactive oxygen species: Are they important for haematopoiesis? 2011. Crit Rev Oncol Hematol. 81(3):257-74

Torres-Rosell J, Losada A. Smc5 flies solo. 2011. Cell Cycle 10: 879-8.

Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. 2011. EMBO Rep. doi: 10.1038/embor.2011.154.

Zaratiegui, M., Castel, S., Irvine, D., Kloc, A., Ren, J., Li, F., de Castro, E., Marín, L., Chang, A., Goto, D., Cande, Z., Antequera, F., Arcangioli B. Martienssen, R. RNAi promotes heterochromatic silencing through replication-coupled release of RNA pol II. 2011. Nature. 479(7371):135-8


Aguilera A, García-Muse T. 2012. R Loops: From Transcription Byproducts to Threats to Genome Stability. Mol. Cell 46:115-124

Almedawar S, Colomina N, Bermúdez-López M, Pociño-Merino I, Torres-Rosell J. 2012. A SUMO-Dependent Step during Establishment of Sister Chromatid Cohesion Curr Biol. 22(17):1576-81

Aparicio T, Megías D, Méndez J. 2012. Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis. Chromosoma. 121(5):499-507

Asensio-Juan E, Gallego C, Martínez-Balbás MA. 2012. The histone demethylase PHF8 is essential for cytoskeleton dynamics. Nucleic Acids Research 40(19):9429-40

Baños B, Villar L, Salas M, de Vega M. 2012. DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. Nucleic Acids Res. 40(19):9750-62

Caron P, Aymard F, Iacovoni JS, Briois S, Canitrot Y, Bugler B, Massip L, Losada A, Legube G. 2012. Cohesin protects genes against ?H2AX Induced by DNA double-strand breaks. PLoS Genet. 8(1):e1002460

Castellano-Pozo M, García-Muse T, Aguilera A.. 2012. R-loops cause replication impairment and genome instability during meiosis. EMBO Rep. 13: 923-929

Castellano-Pozo M, García-Muse T, Aguilera A. 2012. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. PLoS One 7(12):e52447

Cuadrado A, Remeseiro S, Gómez-López G, Pisano DG, Losada A. 2012. The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development. Cell Cycle. 11(12):2233-8

Duch A, de Nadal E, Posas F. 2012. The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses. FEBS Lett. 586(18):2925-31

Ferrezuelo F, Colomina N, Palmisano A, Garí E, Gallego C, Csikász-Nagy A, Aldea M. 2012. The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation. Nat Común 3:1012

Gaillard H, Aguilera A. 2012. Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis. Biochim Biophys Acta. 1829(1):141-50

Gallo-Fernández, M., Saugar, I., Ortiz-Bazán, M. A., Vázquez, M. V. and Tercero, J. A. 2012. Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res. 40(17):8325-8335

García-Rubio ML, Aguilera A. 2012. Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes. Nucleic Acids Res. 40:1050-1064

Hauser, R. Blasche, S. Dokland, T. Haggard-Ljungquist, E. von Brunn, A. Salas, M. Casjens, S. Molineux, I and Uetz, P. 2012. Bacteriophage protein-protein interactions. Advances in Virus Research, Part B. Vol. 83, Burlington:AcademicPress, 219-98

Holguera I, Ballesteros-Plaza D, Muñoz-Espín D, Salas M. 2012. Disclosing the in vivo organization of a viral histone-like protein in Bacillus subtilis mediated by its capacity to recognize the viral genome. Proc Natl Acad Sci U S A. 109(15):5723-8

Holt, J.E., Lane S.I.R., Jennings, P., García-Higuera, I., Moreno, S. and Jones, K.T. 2012. APC(FZR1) prevents non-disjunction in mouse oocytes by controlling meiotic spindle assembly timing. Molecular Biology of the Cell 23:3970-3981.

Joaquin M, Gubern A, González-Nuñez D, Josué Ruiz E, Ferreiro I, de Nadal E, Nebreda AR, Posas F. 2012. The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J. 2012 31(13):2952-64

Joaquin M, Gubern A, Posas F. 2012. A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress. Cell Cycle 11(18):3339-40.

Luna R, Rondón AG, Aguilera A. 2012. New clues to understand the role of THO and other functionally related factors in mRNP biogenesis. Biochim. Biophys. Acta 1819:514-520

Martin MJ, Juarez R, and Blanco L. 2012. DNA binding determinants promoting NHEJ by human Polµ. Nucleic Acids Research 40:11389-11403.

Mendieta, J. Pérez-Lago, L. Salas, M. and Camacho, A. 2012. Functional specificity of a protein-DNA complex mediated by two arginines bound to the minor groove. J. Bacteriol. 194:4727-4735.

Morin JA, Cao FJ, Lázaro JM, Arias-Gonzalez JR, Valpuesta JM, Carrascosa JL, Salas M, Ibarra B. 2012. Active DNA unwinding dynamics during processive DNA replication. Proc Natl Acad Sci U S A. 109(21):8115-20

Muñoz-Espín D, Serrano-Heras G, Salas M. 2012 Role of host factors in bacteriophage f29 DNA replication. Adv Virus Res. 82:351-83.

Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A. 2012. Distinct roles of Mus81, Yen1, Slx1-Slx4 and Rad1 nucleases in the repair of replication-born double strand breaks by sister chromatid exchange. Mol. Cell. Biol. 32:1592-1603

Nadal-Ribelles M, Conde N, Flores O, González-Vallinas J, Eyras E, Orozco M, de Nadal E, Posas F. 2012. Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling. Genome Biol. 13(11):R106.

Pardo B, Aguilera A. 2012. Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases. PLoS Genet. 8(9): e1002979

Pérez-Castro AJ, Freire R. 2012 Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition. J Cell Sci. 125(Pt 5):1152-64

Pérez-Hidalgo, L. and Moreno, S. 2012. Chemical inactivation of Pat1: a novel approach to synchronize meiosis.CellCycle11:1875

Redrejo-Rodríguez, M. Muñoz-Espín, D. Holguera, I. Mencía, M. and Salas, M. 2012. Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages. Proc.Natl.Acad.Sci.USA 109:18482-18487.

Remeseiro S, Cuadrado A, Carretero M, Martínez P, Drosopoulos WC, Cañamero M, Schildkraut CL, Blasco MA, Losada A ( 2012). Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J 31:2076-2089.

Remeseiro S, Cuadrado A, Gómez-López G, Pisano DG, Losada A ( 2012). A unique role of cohesin-SA1 in gene regulation and development. EMBO J 31:2090-2102.

Rivera T, Ghenoiu C, Rodríguez-Corsino M, Mochida S, Funabiki H, Losada A. ( 2012). Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO J. 31:1467-1479

Rodríguez, I. Longás, E. de Vega, M.and Salas, M . 2012. The essential role of the 3´ terminal template base in the first steps of protein-primed DNA replication. PLoS ONE. 7:48257.

Saito H, Posas F. 2012. Response to hyperosmotic stress. Genetics 192(2):289-318.

Seah, M. K.Y., Holt, J., García-Higuera, I., Moreno, S. and Jones, K. T. 2012. The Anaphase-Promoting Complex activator Fizzy-Related-1 (FZR1) is involved in the establishment of a single mitotic spindle in 1-cell embryos and in the mitotic divisions of early mammalian embryos. Journal of Cell Science 125:6030-6037.

Valbuena, N., Guan K.-L. and Moreno, S. 2012. The Vam6-Gtr1/Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Journal of Cell Science 125:1920-1928.

Valbuena, N. and Moreno, S. 2012. AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. Journal of Cell Science 125:2655-2664.

Valbuena, N., Rozalén, A.E. and Moreno, S. 2012. Fission yeast TORC1 prevents eIF2a phosphorylation in response to nitrogen and amino acids via Gcn2 kinase. Journal of Cell Science 125:5955-5959.


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