Selected Publications
2007

Brissett NC, Pitcher RS, Juarez R, Picher AJ, Green AJ, Dafforn TR, Fox GC, Blanco L* and Doherty AJ, 2007. Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science 318:456-459. (IF 26.3)


2008

Aguilera A, Gomez-Gonzalez B, 2008. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 9(3):204-217. (IF 24.1)

Baños B, Lázaro J M,Villar L, Salas M, de Vega M, 2008. Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. J. Mol. Biol. 384: 1019-1028. (IF 4.146)

Baños B, Lázaro J M,Villar L, Salas M, de Vega M, 2008. Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucl. Acids Res. 36:5736-5749. (IF 6.8)

Borlado LR, Mendez J. 2008. CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. Carcinogenesis 29:237-243. (IF 4.9)

Colomina N, Ferrezuelo F, Wang H, Aldea M, Gari E. 2008. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. J Biol Chem 283: 28670-28679. (IF 5.5)

Davis, L., Rozalén, A.E., Moreno, S. , Smith, G.R. and Martín-Castellanos, C. 2008. Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination. Current Biol. 18:849-854. (IF 10.7)

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Méndez, J., Moreno, S. , and Malumbres, M. 2008. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nature Cell Biol 10:802-811. (IF 17.7)

Huertas P, Cortes-Ledesma F, Sartori AA, Aguilera A, Jackson SP, 2008. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455:689-692 (IF 31.4)

Ibarra, A., Schwob, E., and Méndez, J. 2008. Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci USA 105: 8956-8961. [*]

Losada A. 2008. The regulation of sister chromatid cohesion. Biochim. Biophys. Acta 1786:41-48

Pérez-Hidalgo, L., Rozalén, A.E., Martín-Castellanos, C and Moreno, S. 2008. Slk1 is a meiosis-specific Sid2-related kinase that coordinates meiotic nuclear division with growth of the forespore membrane. J. Cell Science 121:1383-1392. (IF 6.2)

Rivera, T., and Losada, A. 2009. Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts. Chromosoma 118:223-33. (IF 5.1)

Salas M, Blanco L, Lazaro JM, de Veja M. 2008. The bacteriophage phi29 DNA polymerase. IUBMB Life 60:82-85. (IF 2.3)

Serrano-Heras, G. Bravo, A. and Salas M. 2008. Phage phi29 protein p56 prevents viral DNA replication impairment caused by uracil excision activity of uracil-DNA glycosylase. Proc. Natl. Acad. Sci. 105:19044-19049. [*]

Vázquez, M. V., Rojas, V. and Tercero, J. A. 2008. Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA. DNA Repair 7:1693-1704. (IF 5.0)


2009

Andrade P, Martín MJ, Juárez R, López de Saro F, Blanco L. 2009. Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. Proc. Natl. Acad. Sci. 106:16203-16208.

Cambray S, Pedraza N, Rafel M, Garí E, Aldea M, Gallego C. 2009. Protein kinase KIS localizes to RNA granules and enhances local translation. Mol. Cell. Biol. 29:726-735 (IF 5.9)

Gomez-Gonzalez B, Aguilera A. 2009. R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX. Nucl. Acids Res. 37(13): 4315-4321 (IF 6.8)

Gomez-Gonzalez B, Felipe-Abrio I, Aguilera A. 2009. The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol. Cell. Biol 29(19):5203-5213 (IF 5.9)

Gozalbo-López B, Andrade P, Terrados G, de Andrés B, Serrano N, Cortegano I, Palacios B, Bernad A, Blanco L, Marcos MA, Gaspar ML. 2009. A role for DNA polymerase mu in the emerging DJH rearrangements of the postgastrulation mouse embryo. Mol. Cell Biol. 29:1266-1275. (IF 5.9)

Ibarra B, Chemla YR, Plyasunov S, Smith SB, Lazaro JM, Salas M, Bustamante C. 2009. Proofreading dynamics of a processive DNA polymerase. EMBO J. 28:2794-2802 (IF 8.2)

Mas G, de Nadal E, Dechant R, de la Concepción ML, Logie C, Jimeno-González S, Chávez S, Ammerer G, Posas F. 2009. Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes. EMBO J. 28:326-36. (IF 8.2)

Muños-Espin D, Daniel R, Hawai Y, Carballido-Lopz R, Castilla-Llorente V, Errington J, Meijer W, Salas M. 2009. The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria. Proc. Natl. Acad. Sci. 106(32):13347-13352

Pardo B, Gomez-Gonzalez B, Aguilera A. 2009. DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship. Cell Mol. Life Sci. 66:1039-1056 (5.5)

Ruiz J F, Gomez-Gonzalez B, Aguilera A. 2009. Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication. Mol. Cell. Biol 29(20):5441-5454 (5.9)

Segurado M, Tercero JA. 2009. The S-phase checkpoint: targeting the replication fork. Biol Cell. 101(11):617-27

Serrano A, Rodríguez-Corsino M, Losada A. 2009. Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells. PLoS One 4: e5118

Tercero JA. 2009. Density transfer as a method to analyze the progression of DNA replication forks. Methods Mol Biol. 521:203-13

Terrados G, Capp J-P, Canitrot Y, García-Díaz M, Bebenek K, Kirchhoff T, Villanueva A, Boudsoq F, Bergoglio V, Cazaux C, Kunkel TA, Hoffmann JS, Blanco L. 2009. Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. PLoS ONE 4(10): e7290. doi:10.1371/journal.pone.0007290

Yaakov G, Duch A, Garcia-Rubio M, Clotet J, Jiménez J, Aguilera A, Posas F. 2009. The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress. Mol. Biol. Cell. 20:3572-3582 (IF 5.5)


2010

Baños, B. Villar, L. Salas, M. and de Vega, M. Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites. 2010. Proc. Natl. Acad. Sci. USA. 107, 19219-19224.

Bermúdez-López M, Ceschia A, de Piccoli G, Colomina N, Pasero P, Aragón L, and Torres-Rosell J. The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. 2010. Nucleic Acids Res. 38:6502-12.

Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L and Doherty AJ. Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase. 2010. Mol. Cell41:221-231.

Capp JP, Boudsocq F, Bergoglio V, Trouche D, Cazaux C, Blanco L, Hoffmann JS, and Canitrot Y. The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. 2010. Carcinogenesis 31, 1742-1747.

Cotobal C, Segurado M and Antequera F. Structural diversity and dynamics of genomic replication origins in Schizosaccharomyces pombe. 2010. EMBO J. 29:934-42.

de Vega M, Lázaro JM, Mencía M, Blanco L, and Salas M. Improvement of f29 DNA polymerase amplification performance by fusion of DNA binding motifs. 2010. Proc. Natl. Acad. Sci. USA. 107, 16506-16511.

Ferreiro I, Joaquin M, Islam A, Gomez-Lopez G, Barragan M, Lombardía L, Domínguez O, Pisano DG, Lopez-Bigas N, Nebreda AR and Posas F. Whole genome analysis of p38 SAPK-mediated gene expression upon stress. 2010 BMC Genomics. 11:144.

Ferreiro I, Barragan M, Gubern A, Ballestar E, Joaquin M and Posas F. The p38 SAPK is recruited to chromatin via its interaction with transcription factors. 2010. J. Biol Chem. 285(41): 31819-28.

Ferrezuelo F, Colomina N, Futcher B and Aldea M. The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle. 2010. Genome Biol. 11:R67

Guillou, E. Ibarra, A. Coulon, V.J. Casado-Vela, J Casal, I. Schwob, E. Losada A. and Méndez, J. Cohesin organizes chromatin loops at DNA replication factories. 2010. Genes Dev. 24(24):2812-22.

Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S, Yamano, H, Cañamero, M, Malumbres, M. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. 2010 Cancer Cell 18, 641-654

Moriel-Carretero, M. and Aguilera, A. A postincision-deficient TFIIH causes replication fork breakage and uncovers alternative Rad51- or Pol32-mediated restart mechanisms. 2010. Mol. Cell 37 (5):690-701.

Muñóz-Espín, D. Holguera, I. Ballesteros-Plaza, D. Carballido-López R. and Salas M. Viral terminal protein directs early organization of phage DNA replication at the bacterial nucleoid 2010. Proc. Natl. Acad. Sci. USA. 107, 16548-16553.

Nieto, C., Almendinger, J., Gysi, S., Kaech, A., Hengartner, M., Schnabel, R., Moreno, S. and Cabello, J. ccz-1 mediates the digestion of apoptotic corpses in C. elegans. 2010. J. Cell Sci. 123, 2001-2007.

Quintales L, Sánchez M and Antequera F. Analysis of DNA strand-specific differential expression with high density tiling microarrays. 2010. BMC Bioinformatics 11: 136

Regot S, Macia J, Conde N, Peeters T, Kentaro F, Kjellen J, Hohmann, S. de Nadal, E, Posas F and Solé R. Distributed biological computation with multicellular engineered networks. 2011. Nature, DOI:10.1038/nature09679. 469(7329):207-11

Sardina JL, López-Ruano G, ... Sánchez-Yagüe J and Hernández-Hernández A. p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation. 2010. Cell Death Differ. 17:1842-54

Valbuena, N. and Moreno, S. TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast. 2010. PloS ONE 5, e11514.

Warringer J, Hult M, Regot S, Posas F and Sunnerhagen P. The HOG pathway dictates the short-term translational response after hyperosmotic shock. 2010. Mol Biol Cell. 21(17): 3080-92.


2011

Adrover MÀ, Zi Z, Duch A, Schaber J, González-Novo A, Jimenez J, Nadal-Ribelles M, Clotet J, Klipp E, Posas, F. Time-dependant quantitive multicomponent control of the GB-S network by the stress-activated protein kinase Hog1 upon osmostress. 2011. Sci. Signal. 4(192):ra63

Asensio, J.L. Pérez-Lago, L. Lázaro, J.M. González, C. Serrano-Heras, G. Salas, M. Novel dimeric structure of phage ø29-encoded protein p56: Insights into uracil-DNA glycosylase inhibiton. 2011. Nucl.Acids Res. 39(22):9779-9788.

Bermejo, R. Capra, T. Jossen, R. Colosio, A. Frattini, C. Carotenuto, W. Cocito, A. Doksani, Y. Klein, H. Gomez-Gonzalez, B. Aguilera, A. Katou, Y. Shirahige, K. Foiani, M. The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. 2011. Cell. 146:233-246

Bernad R, Sánchez P, Rivera T, Rodríguez-Corsino M, Boyarchuk E, Vassias I, Ray-Gallet D, Arnaoutov A, Dasso M, Almouzni G, Losada A. Xenopus HJURP and condensin II are required for CENP-A assembly. 2011. J Cell Biol. 192: 569-82.

Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L, Doherty AJ. Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. 2011. Mol Cell. 41(2):221-31.

Bonfils, S.G.O., Rozalén, A.E., Smith, G.R., Moreno, S. and Martín-Castellanos, C. Functional Interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex. 2011. Journal of Cell Science 124, 1328-1338.

De Castro, E., Soriano, I., Marín, L., Serrano, R., Quintales, L. Antequera, F. Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast. 2011. EMBO J. 31, 124–137

de la Loza, M.C.D. Gallardo, M. Garcia-Rubio, ML. Izquierdo, A. Herrero, E. Aguilera, A. Wellinger, R. Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability. 2011. Nucleic Acids Res. 8:620-626.

de Vega, M. Salas, M. Protein-primed replication of bacteriophage ø29 DNA. DNA Replication/Book. Ed. By Jelena Kusic. 2011. INTECH. ISBN 978-953-307-775-8.

Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. 2011. J Cell Biol. 194 (4):567-79.

Dominguez-Sanchez MS, Saez, C. Japon, MA. Aguilera, A. Luna, R. Differential expression of THOC1 and ALLY mRNP biogenesis/export factors in human cancers. 2011. BMC Cancer 11:77.

Domínguez-Sanchez MS, Barroso S, Gomez-Gonzalez B, Luna R, Aguilera A. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. 2011. PLoS Genetics. 7(12):e1002386.

Fernández RMH, Ruiz-Miró M, Dolcet X, Aldea M, Garí E. Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility. 2011. Oncogene 30: 1936-1946.

Garcia-Rubio ML, Aguilera A. Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes. 2011. Nucleic Acids Res. 40(3):1050-64

Gomez-Gonzalez, B. Garcia-Rubio, M. Bermejo, R. Gaillard, H. Shirahige, K. Marin, A. Foiani, M. Aguilera, A. Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. 2011. EMBO J. 30(15):3106-3119.

Herrero, A.B. and Moreno, S. Lsm1 promotes genomic stability by controlling histone mRNA decay. 2011. EMBO J. 30:2008-2018

Hohl, M. Kwon, Y. Muñoz Galvan, S. Xue, X. Tous, C. Aguilera, A.P. Sung, P. Petrini, J.H.J. The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. 2011. Nat. Struct. Mol. Biol. 18(10):1124-1131

Holt, J.A., Tran, S.M.T., Stewart, J.L., Minahan, K., García-Higuera, I., Moreno, S. and Jones, K.T. The APC/C activator FZR1 co-ordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. 2011. Development 138, 905-913

Mischo. H:E., Gómez-González, B., Grzechnik, P., Rondón, A.G., Wei, W, Steinmetz, L., Aguilera, A.* and Proudfoot, N.J.*. Yeast Sen1 helicase protects the genome from transcription-associated instability. 2011. Mol. Cell 41 (1): 1-12 (*corresponding authors)

Moriel-Carretero M, Tous C, Aguilera A. Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1. 2011. Proc. Natl. Acad. Sci. USA. 108:15300-5

Neukomm, L.J., Andreas P., Frei, A.P., Cabello, J., Ma, X., Haney, L.B., Ravichandran, K.S., Moreno, S. and Hengartner, M.O. RhoGAP SRGP-1 promotes survival and antagonizes clearance of apoptotic cells in C. elegans. 2011. Nature Cell Biology 13, 79-86.

Pérez-Lago, L. Serrano-Heras, G. Baños, B. Lázaro, J.M. Alcorlo, M. Villar, L. and Salas, M. Characterization of /Bacillus subtilis/ Uracil-DNA glycosylase and its inhibition by phage ø29 protein p56. Mol. 2011. Microbiol. 80:1657-1666

Regot S, Macia J, Conde N, Furukawa K, Kjellén J, Peeters T, Hohmann S, de Nadal E, Posas F, Solé R. Distributed biological computation with multicellular engineered networks. 2011. Nature. 469(7329):207-11.

Ruiz, J.F. Gomez-Gonzalez, B. Aguilera A. AID induced double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. 2011. PLos Genetics 7(2): e1002009

Ruiz-Miró M, Colomina N, Fernández RMH, Garí E, Gallego C, Aldea M. Translokin interacts with cyclin D1 and prevents its nuclear accumulation in quiescent cells. 2011. Traffic 12: 549-562

Sanchez, P. Losada, A. New clues to understand how CENP-A maintains centromere identity. 2011. Cell Division 6:11

Sanchez-Berrondo J, Mesa P, Ibarra A, Martínez-Jiménez MI, Blanco L, Méndez J, Boskovic J, Montoya G. 2011. Molecular architecture of a multifunctional MCM complex. Nucleic Acids Res. 40(3):1366-80. doi: 10.1093/nar/gkr831.

Sardina, J.L., López-Ruano, G., Sánchez-Sánchez, B., Llanillo, M., Hernández-Hernández, A. Reactive oxygen species: Are they important for haematopoiesis? 2011. Crit Rev Oncol Hematol. 81(3):257-74

Torres-Rosell J, Losada A. Smc5 flies solo. 2011. Cell Cycle 10: 879-8.

Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. 2011. EMBO Rep. doi: 10.1038/embor.2011.154.

Zaratiegui, M., Castel, S., Irvine, D., Kloc, A., Ren, J., Li, F., de Castro, E., Marín, L., Chang, A., Goto, D., Cande, Z., Antequera, F., Arcangioli B. Martienssen, R. RNAi promotes heterochromatic silencing through replication-coupled release of RNA pol II. 2011. Nature. 479(7371):135-8


2012

Aguilera A, García-Muse T. 2012. R Loops: From Transcription Byproducts to Threats to Genome Stability. Mol. Cell 46:115-124

Almedawar S, Colomina N, Bermúdez-López M, Pociño-Merino I, Torres-Rosell J. 2012. A SUMO-Dependent Step during Establishment of Sister Chromatid Cohesion Curr Biol. 22(17):1576-81

Aparicio T, Megías D, Méndez J. 2012. Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis. Chromosoma. 121(5):499-507

Asensio-Juan E, Gallego C, Martínez-Balbás MA. 2012. The histone demethylase PHF8 is essential for cytoskeleton dynamics. Nucleic Acids Research 40(19):9429-40

Baños B, Villar L, Salas M, de Vega M. 2012. DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. Nucleic Acids Res. 40(19):9750-62

Caron P, Aymard F, Iacovoni JS, Briois S, Canitrot Y, Bugler B, Massip L, Losada A, Legube G. 2012. Cohesin protects genes against ?H2AX Induced by DNA double-strand breaks. PLoS Genet. 8(1):e1002460

Castellano-Pozo M, García-Muse T, Aguilera A.. 2012. R-loops cause replication impairment and genome instability during meiosis. EMBO Rep. 13: 923-929

Castellano-Pozo M, García-Muse T, Aguilera A. 2012. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. PLoS One 7(12):e52447

Cuadrado A, Remeseiro S, Gómez-López G, Pisano DG, Losada A. 2012. The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development. Cell Cycle. 11(12):2233-8

Duch A, de Nadal E, Posas F. 2012. The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses. FEBS Lett. 586(18):2925-31

Ferrezuelo F, Colomina N, Palmisano A, Garí E, Gallego C, Csikász-Nagy A, Aldea M. 2012. The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation. Nat Común 3:1012

Gaillard H, Aguilera A. 2012. Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis. Biochim Biophys Acta. 1829(1):141-50

Gallo-Fernández, M., Saugar, I., Ortiz-Bazán, M. A., Vázquez, M. V. and Tercero, J. A. 2012. Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res. 40(17):8325-8335

García-Rubio ML, Aguilera A. 2012. Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes. Nucleic Acids Res. 40:1050-1064

Hauser, R. Blasche, S. Dokland, T. Haggard-Ljungquist, E. von Brunn, A. Salas, M. Casjens, S. Molineux, I and Uetz, P. 2012. Bacteriophage protein-protein interactions. Advances in Virus Research, Part B. Vol. 83, Burlington:AcademicPress, 219-98

Holguera I, Ballesteros-Plaza D, Muñoz-Espín D, Salas M. 2012. Disclosing the in vivo organization of a viral histone-like protein in Bacillus subtilis mediated by its capacity to recognize the viral genome. Proc Natl Acad Sci U S A. 109(15):5723-8

Holt, J.E., Lane S.I.R., Jennings, P., García-Higuera, I., Moreno, S. and Jones, K.T. 2012. APC(FZR1) prevents non-disjunction in mouse oocytes by controlling meiotic spindle assembly timing. Molecular Biology of the Cell 23:3970-3981.

Joaquin M, Gubern A, González-Nuñez D, Josué Ruiz E, Ferreiro I, de Nadal E, Nebreda AR, Posas F. 2012. The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J. 2012 31(13):2952-64

Joaquin M, Gubern A, Posas F. 2012. A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress. Cell Cycle 11(18):3339-40.

Luna R, Rondón AG, Aguilera A. 2012. New clues to understand the role of THO and other functionally related factors in mRNP biogenesis. Biochim. Biophys. Acta 1819:514-520

Martin MJ, Juarez R, and Blanco L. 2012. DNA binding determinants promoting NHEJ by human Polµ. Nucleic Acids Research 40:11389-11403.

Mendieta, J. Pérez-Lago, L. Salas, M. and Camacho, A. 2012. Functional specificity of a protein-DNA complex mediated by two arginines bound to the minor groove. J. Bacteriol. 194:4727-4735.

Morin JA, Cao FJ, Lázaro JM, Arias-Gonzalez JR, Valpuesta JM, Carrascosa JL, Salas M, Ibarra B. 2012. Active DNA unwinding dynamics during processive DNA replication. Proc Natl Acad Sci U S A. 109(21):8115-20

Muñoz-Espín D, Serrano-Heras G, Salas M. 2012 Role of host factors in bacteriophage f29 DNA replication. Adv Virus Res. 82:351-83.

Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A. 2012. Distinct roles of Mus81, Yen1, Slx1-Slx4 and Rad1 nucleases in the repair of replication-born double strand breaks by sister chromatid exchange. Mol. Cell. Biol. 32:1592-1603

Nadal-Ribelles M, Conde N, Flores O, González-Vallinas J, Eyras E, Orozco M, de Nadal E, Posas F. 2012. Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling. Genome Biol. 13(11):R106.

Pardo B, Aguilera A. 2012. Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases. PLoS Genet. 8(9): e1002979

Pérez-Castro AJ, Freire R. 2012 Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition. J Cell Sci. 125(Pt 5):1152-64

Pérez-Hidalgo, L. and Moreno, S. 2012. Chemical inactivation of Pat1: a novel approach to synchronize meiosis.CellCycle11:1875

Redrejo-Rodríguez, M. Muñoz-Espín, D. Holguera, I. Mencía, M. and Salas, M. 2012. Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages. Proc.Natl.Acad.Sci.USA 109:18482-18487.

Remeseiro S, Cuadrado A, Carretero M, Martínez P, Drosopoulos WC, Cañamero M, Schildkraut CL, Blasco MA, Losada A ( 2012). Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J 31:2076-2089.

Remeseiro S, Cuadrado A, Gómez-López G, Pisano DG, Losada A ( 2012). A unique role of cohesin-SA1 in gene regulation and development. EMBO J 31:2090-2102.

Rivera T, Ghenoiu C, Rodríguez-Corsino M, Mochida S, Funabiki H, Losada A. ( 2012). Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO J. 31:1467-1479

Rodríguez, I. Longás, E. de Vega, M.and Salas, M . 2012. The essential role of the 3´ terminal template base in the first steps of protein-primed DNA replication. PLoS ONE. 7:48257.

Saito H, Posas F. 2012. Response to hyperosmotic stress. Genetics 192(2):289-318.

Seah, M. K.Y., Holt, J., García-Higuera, I., Moreno, S. and Jones, K. T. 2012. The Anaphase-Promoting Complex activator Fizzy-Related-1 (FZR1) is involved in the establishment of a single mitotic spindle in 1-cell embryos and in the mitotic divisions of early mammalian embryos. Journal of Cell Science 125:6030-6037.

Valbuena, N., Guan K.-L. and Moreno, S. 2012. The Vam6-Gtr1/Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Journal of Cell Science 125:1920-1928.

Valbuena, N. and Moreno, S. 2012. AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. Journal of Cell Science 125:2655-2664.

Valbuena, N., Rozalén, A.E. and Moreno, S. 2012. Fission yeast TORC1 prevents eIF2a phosphorylation in response to nitrogen and amino acids via Gcn2 kinase. Journal of Cell Science 125:5955-5959.


2013

Aguilera A, García-Muse T. 2013. Causes of genome instability. Annu Rev Genet. 47:1-32.

Aza A, Martin MJ, Juarez R, Blanco L, and Terrados G. 2013. DNA expansions generated by human Polµ on iterative sequences. Nucleic Acids Research 41:253-263

Balbás-Martínez C, Sagrera A, Carrillo-de-Santa-Pau E, Earl J, Márquez M, Vazquez M, Lapi E, Castro-Giner F, Beltran S, Bayés M, Carrato A, Cigudosa JC, Domínguez O, Gut M, Herranz J, Juanpere N, Kogevinas M, Langa X, López-Knowles E, Lorente JA, Lloreta J, Pisano DG, Richart L, Rico D, Salgado RN, Tardón A, Chanock S, Heath S, Valencia A, Losada A, Gut I, Malats N, Real FX. 2013. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet. 45(12):1464-9.

Ballesteros-Plaza D, Holguera I, Scheffers DJ, Salas M, Muñoz-Espín D. 2013. Phage 29 protein p1 promotes replication by associating with the FtsZ ring of the divisome in Bacillus subtilis. Proc Natl Acad Sci U S A. 110(30):12313-8.

Baños-Sanz JI, Mojardín L, Sanz-Aparicio J, Lázaro JM, Villar L, Serrano-Heras G, González B, Salas M. 2013. Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage F29 DNA mimic protein p56. Nucleic Acids Res. 41(13):6761-73.

Brissett NC, Martin MJ, Bartlett EJ, Bianchi J, Blanco L, Doherty AJ. 2013. Molecular basis for DNA double-strand break annealing and primer extension by an NHEJ DNA polymerase. Cell Rep. 5(4):1108-20

Carretero M, Ruiz-Torres M, Rodríguez-Corsino M, Barthelemy I, Losada A. 2013. Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J. 32(22):2938-49.

Castellano-Pozo M, Santos-Pereira JM, Rondón AG, Barroso S, Andújar E, Pérez-Alegre M, García-Muse T, Aguilera A. 2013. R loops are linked to histone H3 S10 phosphorylation and chromatin condensation. Mol Cell. 52(4):583-90.

Delgado-Esteban M, García-Higuera I, Maestre C, Moreno S, Almeida A. 2013. APC/C-Cdh1 coordinates neurogenesis and cortical size during development. Nat Commun. 4:2879.

Del Prado A, Lázaro JM, Villar L, Salas M, de Vega M. 2013. Dual Role of f29 DNA Polymerase Lys529 in Stabilisation of the DNA Priming-Terminus and the Terminal Protein-Priming Residue at the Polymerisation Site. PLoS One. 8(9):e72765.

Duch A, de Nadal E, Posas F. 2013. Dealing with Transcriptional Outbursts during S Phase to Protect Genomic Integrity. J Mol Biol. 425(23):4745-55

Duch A, Felipe-Abrio I, Barroso S, Yaakov G, García-Rubio M, Aguilera A, Nadal E, Posas F. 2013. Coordinated control of replication and transcription by a SAPK protects genomic integrity. Nature 493(7430):116-9.

Esteban V, Martin MJ, Blanco L. 2013. The BRCT domain and the specific loop 1 of human Polµ are targets of Cdk2/cyclin A phosphorylation. DNA Repair (Amst). 12(10):824-34

Fernández-Hernández R, Rafel M, Fusté NP, Aguayo RS, Casanova JM, Egea J, Ferrezuelo F, Garí E. 2013. Cyclin D1 localizes in the cytoplasm of keratinocytes during skin differentiation and regulates cell-matrix adhesion. Cell Cycle 12(15):2510-7.

Gaillard H, Herrera-Moyano E, Aguilera A. 2013. Transcription-associated genome instability. Chem Rev. 113(11):8638-61.

Gaillard H, Aguilera A. 2013. Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis. Biochim Biophys Acta. 1829(1):141-50.

Garrido P, Mejia E, Garcia-Diaz M, Blanco L, Picher AJ. 2014. The active site of TthPolX is adapted to prevent 8-oxo-dGTP misincorporation. Nucleic Acids Res. 42(1):534-43

Garcia-Gomez S, Reyes A, Martinez-Jimenez MI, Chocrón ES, Mouron S, Terrados G, Powell C, Salido, E, Mendez J, Holt IJ and Blanco L. 2013. PrimPol, an archaic primase/polymerase operating in human cells. Molecular Cell 52(4):541-53

Gavaldá S, Gallardo M, Luna R, Aguilera A. 2013. R-loop mediated transcription-associated recombination in trf4? mutants reveals new links between RNA surveillance and genome integrity. PLoS One. 8(6):e65541.

Gómez-Orte E, Sáenz-Narciso B, Moreno S, Cabello J. 2013. Multiple functions of the noncanonical Wnt pathway. Trends Genet. 29(9):545-53.

Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA. 2013. Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Res. 41(22):10298-311

Kakarougkas A, Ismail A, Klement K, Goodarzi AA, Conrad S, Freire R, Shibata A, Lobrich M, Jeggo PA. 2013. Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Res.41(21):9719-31

López-Contreras AJ, Ruppen I, Nieto-Soler M, Murga M, Rodríguez-Acebes S, Remeseiro S, Rodrigo-Pérez S, Rojas AM, Méndez J, Muñoz J, Fernández-Capetillo O. 2013. A proteomic characterization of factors enriched at nascent DNA molecules. Cell Rep 3(4):1105-1116.

Lucas D, Delgado-García JM, Escudero B, Albo C, Aza A, Acín-Pérez R, Torres Y, Moreno P, Enríquez JA, Samper E, Blanco L, Fairén A, Bernad A, Gruart A. 2013. Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase µ. PLoS One. 8(1):e53243.

Lyndaker AM, Lim PX, Mleczko JM, Diggins CE, Holloway JK, Holmes RJ, Kan R, Schlafer DH, Freire R, Cohen PE, Weiss RS. 2013. Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. Plos Genetics. 9:e1003320.

Martin MJ, Garcia-Ortiz MV, Esteban V and Blanco L. 2013. Ribonucleotides and manganese ions improve non-homologous end-joining by human Polµ. Nucleic Acids Research, 41:2428-2436

Martin MJ, Garcia-Ortiz MV, Gomez-Bedoya A, Esteban V, Guerra S, Blanco L. 2013. A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polµ and Pol?. Nucleic Acids Res. 41(19):9105-16

Menoyo S, Ricco N, Bru S, Hernández-Ortega S, Escoté X, Aldea M, Clotet J. Phosphate-activated cyclin-dependent kinase stabilizes g1 cyclin to trigger cell cycle entry. 2013. Mol Cell Biol. 33(7):1273-84.

Merriman, J.A., Lane, S.I.R., Holt, J.E., Jennings, P.C., García-Higuera, I., Moreno, S., McLaughlin, E.A. and Jones, K.T. 2013. Chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice. Biology of Reproduction 88(2):31.

Mojardín L, Botet J, Quintales L, Moreno S and Salas M. 2013. New insights into the RNA-based mechanism of action of the anticancerdrug 5´-Fluorouracil in eukaryotic cells. PLoSOne. 8(11):e78172

Mojardín L, Vázquez E, Antequera F. 2013. Specification of DNA replication origins and genomic base composition in fission yeasts. J Mol Biol. 425(23):4706-13.

Mourón S, Rodriguez-Acebes S, Martínez-Jiménez MI, García-Gómez S, Chocrón S, Blanco L, Méndez J. 2013. Repriming of DNA synthesis at stalled replication forks by human PrimPol. Nat Struct Mol Biol. 20(12):1383-9.

Muñoz-Galván S, López-Saavedra A, Jackson SP, Huertas P, Cortés-Ledesma F, Aguilera A, 2013. Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination. Nucleic Acid. Res. 41(3):1669-1683.

Muñoz-Galván S, Jimeno S, Rothstein R, Aguilera A. 2013. Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid. PLoS Genet. 9(1):e1003237.

Ontoso D, Acosta I, van Leeuwen F, Freire R, San-Segundo PA.. 2013. Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor. Plos Genetics. 9:e1003262.

Redrejo-Rodríguez, M. Muñoz-Espín, D. Holguera, I. Mencía, M.and Salas, M. 2013. Nuclear localization signals in phage terminal proteins provide a novel gene delivery tool in mammalian cells. Commun Integr Biol. 6(2):e22829.

Redrejo-Rodríguez, M. Muñoz-Espín, D. Holguera, I. Mencía, M.and Salas, M. 2013. Nuclear and nucleoid localization are independently conserved functions in bacteriophage terminal proteins. Mol. Microbiol. 90(4):858-68

Regot S, de Nadal E, Rodríguez-Navarro S, González-Novo A, Pérez-Fernandez J, Gadal O, Seisenbacher G, Ammerer G, Posas F. 2013. The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress. J Biol Chem. 288(24):17384-98.

Remeseiro S, Cuadrado A, Kawauchi S, Calof AL, Lander AD, Losada A. 2013. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim Biophys Acta 1832, 2097-2102.

Remeseiro S, Losada A. Cohesin, 2013. A chromatin engagement ring. Curr Opin Cell Biol. 25(1):63-71.

Ruiz JF, Pardo B, Sastre-Moreno G, Aguilera A, Blanco L. 2013. Yeast pol4 promotes tel1-regulated chromosomal translocations. PLoS Genet. 9(7):e1003656.

Santos-Pereira JM, Herrero AB, García-Rubio ML, Marín A, Moreno S, Aguilera A. 2013. The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability. Genes Dev. 27(22):2445-58

Saugar I, Vazquez MV, Gallo-Fernandez M, Ortiz-Bazan MA, Segurado M, Calzada A, Tercero JA. 2013. Temporal regulation of the Mus81-Mms4 endonuclease ensures cells survival under conditions of DNA damage. Nucleic Acids Res. 41(19):8943-58

Soriano I, Quintales L, Antequera F. 2013. Clustered regulatory elements at nucleosome-depleted regions punctuate a constant nucleosomal landscape in Schizosaccharomyces pombe. BMC Genomics. 14:813.

Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA. 2013. UV-induced G2 checkpoint depends on p38 MAPK and minimal activacion of ATR-Chk1 pathway. J. Cell Sci. 126(Pt9):1923-30


2014

Aguilera A, Gaillard H. Transcription and recombination: when RNA meets DNA. Cold Spring Harb Perspect Biol. 6(8). pii: a016543.

Baquero-Montoya C, Gil-Rodríguez M, Teresa-Rodrigo M, Hernández-Marcos M, Bueno-Lozano G, Bueno-Martínez I, Remeseiro S, Fernández-Hernández R, Bassecourt-Serra M, Rodríguez de Alba M, Queralt E, Losada A, Puisac B, Ramos F, Pié J. Could a patient with SMC1A duplication be classified as a human cohesinopathy? Clin Genet 85, 446-451.

Bhatia V, Barroso SI, García-Rubio ML, Tumini E, Herrera-Moyano E, Aguilera A. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. Nature. 511(7509):362-5.

Bruinsma W, Macurek L, Freire R, Lindqvist A, Medema RH. Bora and Aurora-A continue to activate Plk1 in mitosis. J Cell Sci. 127(Pt 4):801-11.

Burenina OY, Hoch PG, Damm K, Salas M, Zatsepin TS, Lechner M, Oretskaya TS, Kubareva EA, and Hartmann RK. Mechanistic comparison of Bacillus subtilis 6S-1 and 6S-2 RNAs – commonalities and differences. Nucleic Acids Res. 20:348-359.

Castel SE, Ren J, Bhattacharjee S, Chang AY, Sánchez M, Valbuena A, Antequera F, Martienssen RA. Dicer promotes transcription termination at sites of replication stress to maintain genome stability. Cell. 159(3):572-83.

Dahl JM, Wang H, Lázaro JM, Salas M and Lieberman KR. Dynamics of translocation and substrate binding in individual complexes formed with active site mutants of ø29 DNA polymerase. J. Biol. Chem. 289:6350-6361.

Delgado-Díaz MR, Martín Y, Berg A, Freire R, Smits VA. Dub3 controls DNA damage signalling by direct deubiquitination of H2AX. Mol Oncol. 8(5):884-93.

Escudero B, Lucas D, Albo C, Dhup S, Bacher JW, Sánchez-Muñoz A, Fernández M, Rivera-Torres J, Carmona RM, Fuster E, Carreiro C, Bernad R, González MA, Andrés V, Blanco L, Roche E, Fabregat I, Samper E, Bernad A. Polµ deficiency increases resistance to oxidative damage and delays liver aging. PLoS One. 9(4):e93074.

Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Méndez J, Morrison CG, Passegué E. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. 512(7513):198-202.

Gaillard H, Aguilera A. Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae. PLoS Genet. 10(3):e1004203.

Garrido P, Mejia E, Garcia-Diaz M, Blanco L, Picher AJ. The active site of TthPolX is adapted to prevent 8-oxo-dGTP misincorporation. Nucleic Acids Res. 42(1):534-43.

Gella P, Salas M, Mencía M. Improved artificial origins for phage F29 terminal protein-primed replication. Insights into early replication events. Nucleic Acids Res. 2014 Nov 1;42(15):9792-806.

Herrera-Moyano E, Mergui X, García-Rubio ML, Barroso S, Aguilera A. The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts. Genes Dev. 2014 Apr 1;28(7):735-48.

Holguera I, Redrejo-Rodríguez M, Salas M, Muñoz-Espín D. New insights in the ?29 terminal protein DNA-binding and host nucleoid localization functions. Mol Microbiol. 91(2):232-41.

Holt JE, Pye V, Boon E, Stewart JL, García-Higuera I, Moreno S, Rodríguez R, Jones KT, McLaughlin EA. The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development. 141(6):1354-65.

Losada A. Cohesin in cancer: chromosome segregation and beyond. Nat Rev Cancer 14, 389-393.

Martin MJ, Blanco L. Decision-making during NHEJ: a network of interactions in human Polµ implicated in substrate recognition and end-bridging. Nucleic Acids Res. 42(12):7923-34.

Mojardín L, Botet J, Moreno S, Salas M. Chromosome segregation and organization are targets of 5´-Fluorouracil in eukaryotic cells. Cell Cycle 14, 206-218.

Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F. Control of Cdc28 CDK1 by a stress-induced lncRNA. Mol Cell. 53(4):549-61

Ortiz-Bazán MA, Gallo-Fernández M, Saugar I, Jiménez-Martín A, Vázquez MV, Tercero JA. Rad5 plays a major role in the cellular response to DNA damage during chromosome replication.Cell Rep. 9: 460-468.

Pedraza N, Ortíz R, Cornadó A, Llobat A, Aldea M, Gallego C. KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling. Journal of Neuroscience, 34:13988-97

Redrejo-Rodriguez M, Salas M. Multiple roles of genome-attached bacteriophage terminal proteins. Virology 15:468-470.

Santos E, Lázaro JM, Pérez-Arnaiz P, Salas M, de Vega M. Role of the LEXE motif of protein-primed DNA polymerases in the interaction with the incoming nucleotide. J Biol Chem. 289(5):2888-98.

Santos-Pereira JM, Herrero AB, Moreno S, Aguilera A. Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity. Cell Cycle. 13(10):1524-9.

Sardina JL, López-Ruano G, Prieto-Bermejo R, Sánchez-Sánchez B, Pérez-Fernández A, Sánchez-Abarca LI, Pérez-Simón JA, Quintales L, Sánchez-Yagüe J, Llanillo M, Antequera F, Hernández-Hernández A. PTPN13 regulates cellular signalling and ß-catenin function during megakaryocytic differentiation. Biochim Biophys Acta. 1843(12):2886-2899.

Sastre-Moreno G, Sánchez A, Esteban V, Blanco L. ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe. Nucleic Acids Res. 42(15):9821-37.

Saugar I, Ortiz-Bazán MA, Tercero JA. Tolerating DNA damage during eukaryotic chromosome replication. Exp Cell Res. 329: 170-177.

Soriano I, Morafraile E, Vázquez E, Antequera F and Segurado, M. Different nucleosomal architectures at early and late replication origins in Saccharomyces cerevisiae. BMC Genomics 15(1):791

Yahya G, Parisi E, Flores A, Gallego C, Aldea M. A whi7-anchored loop controls the g1 cdk-cyclin complex at start. Mol Cell. 53(1):115-26.

Zeman MK, Lin JR, Freire R, Cimprich KA. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol. 206(2):183-97.


2015

Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J. Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun. 6:8548.

Berjón-Otero M, Villar L, de Vega M, Salas M, Redrejo-Rodríguez M. DNA polymerase from temperate phage Bam35 is endowed with processive polymerization and a basic sites translesion synthesis capacity. Proc.Natl.Acad.Sci.USA. 112(27):E3476-84

Bermúdez-López M, Pociño-Merino I, Sánchez H, Bueno A, Guasch C, Almedawar S, Bru-Virgili S, Garí E, Wyman C, Reverter D, Colomina N, Torres-Rosell J. ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair. PLoS Biol. 13(3):e1002089.

Bravo M, Nicolini F, Starowicz K, Barroso S, Calés C, Aguilera A, Vidal M. Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression. J Cell Sci. 128(19):3660-71.

Cuadrado A, Remeseiro S, Graña O, Pisano DG, Losada A. The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues. Nucleic Acids Res 43:3056-67.

De Nadal E, Posas F. Osmostress-induced gene expression; a model to understand how stress-activated protein kinases (SAPKs) regulate transcription. FEBS J. doi: 10.1111/febs.13323.

Del Prado A, Lázaro JM, Longás E, Villar L, De Vega M, Salas M. Insights into the determination of the templating nucleotide at the initiation of f29 DNA replication. J.Biol.Chem. 290, 27138-27145.

Fornelos N, Butala M, Hodnik V, Anderluh G, Bamford JK, Salas M. Bacteriophage GIL01 gp7 interacts with host LexA repressor to enhance DNA binding and inhibit RecA-mediated auto-cleavage. Nucleic Acids Res. 43:7315-7319

Gaillard H, García-Muse T, Aguilera A. Replication stress and cancer. Nat Rev Cancer. 15(5):276-89.

Gaillard H, Wellinger RE, Aguilera A. Methods to study transcription-coupled repair in chromatin. Methods Mol Biol. 1288:273-88

García-Rubio ML, Pérez-Calero C, Barroso SI, Tumini E, Herrera-Moyano E, Rosado IV, Aguilera A. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet. 11(11):e1005674.

Georgieva MV, Yahya G, Codó L, Ortiz R, Teixidó L, Claros J, Jara R, Jara M, Iborra A, Gelpí JL, Gallego C, Orozco M, Aldea M. Inntags: small self-structured epitopes for innocuous protein tagging. Nature Methods 12: 955–958

Gong EY, Smits VA, Fumagallo F, Piscitello D, Morrice N, Freire R, Gillespie DA. KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage. Sci Rep. 5:10856.

González-Novo A, Jiménez J, Clotet J, Nadal-Ribelles M, Cavero S, de Nadal E, Posas F. Hog1 targets Whi5 and Msa1 transcription factors to down-regulate cyclin expression upon stress. Mol Cell Biol. 35(9):1606-18.

Hohl M, Kocha?czyk T, Tous C, Aguilera A, Kr??el A, Petrini JH. Interdependence of the rad50 hook and globular domain functions. Mol Cell 57(3):479-91

Holguera I, Muñoz-Espín D, Salas M. Dissecting the role of DNA-binding residues of the ø29 terminal protein in viral DNA replication. Nucleic Acids Res. 43:2790-801

Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O. NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J. 34(21):2604-19.

Krizaic I, Williams SJ, Sánchez P, Rodríguez-Corsino M, Stukenberg PT, Losada A. The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts. Nucleus 8:1-11

Martínez-Jiménez MI, García-Gómez S, Bebenek K, Sastre-Moreno G, Calvo PA, Díaz-Talavera A, Kunkel TA, Blanco L. Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol. DNA Repair (Amst). 29:127-38

Materne P, Anandhakumar J, Migeot V, Soriano I, Yague-Sanz C, Hidalgo E, Mignion C, Quintales L, Antequera F & Hermand D. Promoter nucleosome dynamics regulated by signaling through the CTD code eLIFE (doi: 10.7554/eLife.09008)

Modzelewski AJ, Hilz S, Crate EA, Schweidenback CT, Fogarty EA, Grenier JK, Freire R, Cohen PE, Grimson A. Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males. J Cell Sci. 128(12):2314-27.

Mojardín L, Botet J, Moreno S, Salas M. Chromosome segregation and organization are targets of 5´-Fluorouracil in eukaryotic cells. Cell Cycle 14:206-218.

Morafraile EC, Diffley JFX, Tercero JA, Segurado M. Checkpoint-dependent RNR induction promotes fork restart after replicative stress. Sci. Rep 5:7886.

Moriel-Carretero M, Herrera-Moyano E, Aguilera A. A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome. Rare Dis. 3(1):e1079362.

Morin JA, Cao FJ, Lázaro JM, Arias-Gonzalez JR, Valpuesta JM, Carrascosa JL, Salas M, Ibarra B. Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase. Nucleic Acids Res. 43, 3643-3652.

Nadal-Ribelles M, Mas G, Millan G, Solé C, Ammerer G, Chavez S, Posas F, de Nadal E. H3K4 Monomethylation Dictates Nucleosome Dynamics and Chromatin Remodeling at Stress Responsive Genes. Nucleic Acids Research. 43(10):4937-49

Pryor JM, Waters CA, Aza A, Asagoshi K, Strom C, Mieczkowski PA, Blanco L, Ramsden DA. Essential role for polymerase specialization in cellular nonhomologous end joining. Proc Natl Acad Sci U S A. 112(33):E4537-45.

Quintales L, Soriano I, Vázquez E, Segurado M, Antequera F. A species-specific nucleosomal signature defines a periodic distribution of amino acids in proteins. Open Biology 5: 140218 (doi: 10.1098/rsob.140218)

Quintales L, Vázquez E, Antequera F. Comparative analysis of methods for genome-wide nucleosome cartography. Briefings in Bioinformatics 16: 576-587

Santos-Pereira JM, Aguilera A. R loops: new modulators of genome dynamics and function. Nat Rev Genet. 16(10):583-97.

Sharifian H, Lampert F, Stojanovski K, Regot S, Vaga S, Buser R, Lee SS, Koeppl H, Posas F, Pelet S, Peter M. Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade. Integr Biol (Camb). 7(4):412-22.

Solé C, Nadal-Ribelles M, de Nadal E, Posas F. A novel role for lncRNAs in cell cycle control during stress adaptation. Curr Genet. 61(3):299-308 (2015).

Stuckey R, García-Rodríguez N, Aguilera A, Wellinger RE. Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system. Proc Natl Acad Sci U S A. 112(18):5779-84.

Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M. Functional reprogramming of polyploidization in megakaryocytes. Dev Cell 32:155-167.

Vázquez E, Antequera F. Replication dynamics in fission and budding yeasts via DNA polymerase tracking. Bio Essays 37:1067-1073


2016

Abe T, Kawasumi R, Arakawa H, Hori T, Shirahige K, Losada A, Fukagawa T, Branzei D. Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion. Oncotarget. 7(42):67934-67947

Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun. 2016 Feb 15;7:10660. doi: 10.1038/ncomms10660.

Amaral N, Vendrell A, Funaya C, Idrissi FZ, Maier M, Kumar A, Neurohr G, Colomina N, Torres-Rosell J, Geli MI, Mendoza M. The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress. Nat Cell Biol. 18(5):516-26.

Andersen SL, Zhang A, Dominska M, Moriel-Carretero M, Herrera-Moyano E, Aguilera A, Petes TD. High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast. PLoS Genet. 12(3):e1005938.

Baleriola J, Álvarez-Lindo N, de la Villa P, Bernad A, Blanco L, Suárez T, de la Rosa EJ. Increased neuronal death and disturbed axonal growth in the Pol?-deficient mouse embryonic retina. Sci Rep. 6:25928.

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